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Anesthesia and neurodevelopment after 20 years: where are we now and where to next?

by SmartTots | Jan 4, 2023 | Clinical Articles, Research Articles

This editorial discusses recent government warnings on anesthesia in pregnant women and young children, the latest findings from clinical trials, unanswered questions about anesthesia and its association to neurotoxicity, and new directions in pediatric anesthesia...

Environmental enrichment holds promise as a novel treatment for anesthesia-induced neurocognitive disorders.

by SmartTots | Jan 4, 2023 | Clinical Articles, Research Articles

Abstract In recent years, since the need for anesthetic interventions in pregnant women, newborns, and older patients has been increasing, the anesthesia-induced cognitive impairment has received widespread attention and highlighted the urgent requirement for...

Readability, Content, and Quality of Online Patient Education Materials on Anesthesia and Neurotoxicity in the Pediatric Population.

by SmartTots | Jan 4, 2023 | Clinical Articles, Research Articles

Abstract Objective: Internet-based patient education materials (PEMs) are often above the recommended sixth grade reading level recommended by the U.S. Department of Health and Human Services. In 2016 the U.S. Food and Drug Administration (FDA) released a warning...

Analgesia, Sedation, and Anesthesia for Neonates With Cardiac Disease.

by SmartTots | Jan 4, 2023 | Clinical Articles, Research Articles

Abstract Analgesia, sedation, and anesthesia are a continuum. Diagnostic and/or therapeutic procedures in newborns often require analgesia, sedation, and/or anesthesia. Newborns, in general, and, particularly, those with heart disease, have an increased risk of...

Association of sedation and anesthesia on cognitive outcomes in very premature infants: a retrospective observational study.

by SmartTots | Jan 4, 2023 | Clinical Articles, Research Articles

Abstract Purpose: Cognitive outcomes in preterm infants may be adversely affected by use of sedation and anesthetic agents. We investigated the associations between anesthetics/sedatives and full-scale intelligence quotient (FSIQ) measured at 36 months corrected age...

Consequences of General Anesthesia in Infancy on Behavior and Brain Structure.

by SmartTots | Jan 4, 2023 | Clinical Articles, Research Articles

Abstract BACKGROUND: One in 7 children will need general anesthesia (GA) before the age of 3. Brain toxicity of anesthetics is controversial. Our objective was to clarify whether exposure of GA to the developing brain could lead to lasting behavioral and structural...
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Recent Posts

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  • Single-nucleus atlas of sevoflurane-induced hippocampal cell-type- and sex-specific effects during development in mice.
  • Ketamine impairs growth cone and synaptogenesis in human GABAergic projection neurons via GSK-3β and HDAC6 signaling.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

90 New Montgomery Street
Suite 412
San Francisco, CA 94105
Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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