by SmartTots | Jan 4, 2024 | Preclinical Articles, Research Articles
Abstract Background: Prenatal spina bifida aperta repair improves neurologic outcomes yet comes with a significant risk of prematurity and uterine scar-related complications. To reduce such complications, different fetoscopic techniques, for example, with varying...
by SmartTots | Jan 4, 2024 | Preclinical Articles, Research Articles
Abstract Background: Sevoflurane, a commonly administered inhaled anesthetic, is found to induce synaptic and mitochondrial damage in neonatal mice. Mitochondrial membrane potential (MMP) changes, mediated by Cyclophilin D (CypD), are implicated in mitochondrial...
by SmartTots | Jan 4, 2024 | Preclinical Articles, Research Articles
Abstract Sevoflurane (SEV) is a commonly used anesthetic in pediatric surgery. Recent studies reported that repeated use of SEV contributes to cognitive impairment. Engeletin has been discovered to exert anti-inflammatory effects in various diseases. However, the...
by SmartTots | Jan 4, 2024 | Preclinical Articles, Research Articles
Abstract Background: Sevoflurane is a widely used anesthetic in infants. However, long and repeated exposure to this drug can cause developmental neurotoxicity. This study aimed to investigate the role and mechanism of circular RNA DLGAP4 (circDLGAP4) in...
by SmartTots | Jan 4, 2024 | Preclinical Articles, Research Articles
Abstract Objective: To investigate whether propofol can cause injury to hippocampal mitochondria in neonatal rats and the regulation of excitatory amino acid receptor AMPA receptor. Methods: Forty-eight Sprague-Dawley (SD) rats aged 7 days were randomly divided into...
by SmartTots | Jan 4, 2024 | Preclinical Articles, Research Articles
Abstract Objective: To explore the molecular mechanism of propofol-induced apoptosis in oligodendrocytes. Methods: Fortyfive neonatal (7 days old) SD rats were randomized into 3 groups (n=15) for a single intraperitoneal injection of saline (control), long chain fat...
