by SmartTots | Feb 13, 2026 | Preclinical Articles, Research Articles
Abstract Background: Sevoflurane induces neuronal dysfunction and cognitive impairment. However, the underlying mechanism remains largely to be determined. Tau, cyclophilin D, and dendritic spine contribute to cognitive function. But whether changes in dendritic...
by SmartTots | Feb 13, 2026 | Preclinical Articles, Research Articles
In this video presentation, which is part of the SAFETOTS/S.A.R.N.eP.I online webinar series, Dr. Laszlo Vutskits discusses key points related to improving pediatric neurological outcomes, including whether there is a biological rationale for perioperative...
by SmartTots | Jan 4, 2024 | Preclinical Articles, Research Articles
Abstract Background: Prenatal spina bifida aperta repair improves neurologic outcomes yet comes with a significant risk of prematurity and uterine scar-related complications. To reduce such complications, different fetoscopic techniques, for example, with varying...
by SmartTots | Jan 4, 2024 | Preclinical Articles, Research Articles
Abstract Background: Sevoflurane, a commonly administered inhaled anesthetic, is found to induce synaptic and mitochondrial damage in neonatal mice. Mitochondrial membrane potential (MMP) changes, mediated by Cyclophilin D (CypD), are implicated in mitochondrial...
by SmartTots | Jan 4, 2024 | Preclinical Articles, Research Articles
Abstract Sevoflurane (SEV) is a commonly used anesthetic in pediatric surgery. Recent studies reported that repeated use of SEV contributes to cognitive impairment. Engeletin has been discovered to exert anti-inflammatory effects in various diseases. However, the...
by SmartTots | Jan 4, 2024 | Preclinical Articles, Research Articles
Abstract Background: Sevoflurane is a widely used anesthetic in infants. However, long and repeated exposure to this drug can cause developmental neurotoxicity. This study aimed to investigate the role and mechanism of circular RNA DLGAP4 (circDLGAP4) in...
