by SmartTots | Nov 3, 2023 | Preclinical Articles, Research Articles
Abstract Background Clinical studies suggest that anaesthesia exposure early in life affects neurobehavioural development. We designed a non-human primate (NHP) study to evaluate cognitive, behavioural, and brain functional and structural alterations after isoflurane...
by SmartTots | Sep 1, 2023 | Preclinical Articles, Research Articles
The editors highlight eight “intriguing” papers on age-dependent anesthetic effects in the developing brain, their mechanisms, and clinical applications. Important topics include 1) mechanisms underlying anesthesia-induced neurotoxicity and cognitive impairments in...
by SmartTots | Sep 1, 2023 | Preclinical Articles, Research Articles
Abstract With advances in pediatric and obstetric surgery, pediatric patients are subject to complex procedures under general anesthesia. The effects of anesthetic exposure on the developing brain may be confounded by several factors including pre-existing disorders...
by SmartTots | Sep 1, 2023 | Preclinical Articles, Research Articles
Abstract Background: The volatile anaesthetic sevoflurane induces time (single or multiple exposures)-dependent effects on tau phosphorylation and cognitive function in young mice. The underlying mechanism for this remains largely undetermined. Methods: Mice received...
by SmartTots | Sep 1, 2023 | Preclinical Articles, Research Articles
Abstract Objective: Dexmedetomidine (DEX), a selective α2-adrenoceptor agonist, is an anesthetic and sedative agent and has been reported to confer neuroprotective effects after cerebral hypoxic ischemia (CHI). This study was undertaken to elucidate the mechanisms by...
by SmartTots | Sep 1, 2023 | Preclinical Articles, Research Articles
Abstract This study is to investigate the function of miR-34a and interactions between miR-34a, SIRT1, and p53 in sevoflurane-induced neuronal apoptosis and autophagy in neonatal mice. A mouse model was established by inhalation anesthesia with sevoflurane and...
