by SmartTots | Feb 14, 2023 | Preclinical Articles, Research Articles
Abstract Sevoflurane is the primary inhaled anesthetic used in pediatric surgery. It has been the focus of research since animal models studies found that it was neurotoxic to the developing brain two decades ago. However, whether pediatric general anesthesia can lead...
by SmartTots | Feb 14, 2023 | Preclinical Articles, Research Articles
Abstract Sevoflurane is widely used for maternal anesthesia during pregnancy. Sevoflurane exposure of rats at mid-gestation can cause abnormal development of the central nervous system in their offspring. Sevoflurane is known to increase the expression of cannabinoid...
by SmartTots | Feb 14, 2023 | Preclinical Articles, Research Articles
Abstract With the development of technology, more infants receive general anesthesia for surgery, other interventions, or clinical examination at an early stage after birth. However, whether general anesthetics can affect the function and structure of the developing...
by SmartTots | Feb 14, 2023 | Preclinical Articles, Research Articles
Abstract Exposure to surgery with anesthesia early in life may lead to abnormal behavior, learning, and memory in humans. Pre-clinical studies have suggested a critical role of glial cell-derived neurotrophic factor (GDNF) in these effects. We hypothesize that the...
by SmartTots | Feb 14, 2023 | Preclinical Articles, Research Articles
Abstract Introduction: Sevoflurane is the most commonly used general anesthetic in pediatric surgery, but it has the potential to be neurotoxic. Previous research found that long-term or multiple sevoflurane exposures could cause cognitive deficits in newborn mice but...
by SmartTots | Feb 14, 2023 | Preclinical Articles, Research Articles
Abstract Growing animal studies suggest a risk of neuronal damage following early childhood exposure to anesthesia and sedation drugs including propofol. Inhibition of transient receptor potential canonical 6 (TRPC6) degradation has been shown to protect neurons from...
