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Long-term sevoflurane exposure resulted in temporary rather than lasting cognitive impairment in Drosophila.

by SmartTots | Feb 14, 2023 | Preclinical Articles, Research Articles

Abstract Sevoflurane is the primary inhaled anesthetic used in pediatric surgery. It has been the focus of research since animal models studies found that it was neurotoxic to the developing brain two decades ago. However, whether pediatric general anesthesia can lead...

Maternal sevoflurane exposure induces neurotoxicity in offspring rats via the CB1R/CDK5/p-tau pathway.

by SmartTots | Feb 14, 2023 | Preclinical Articles, Research Articles

Abstract Sevoflurane is widely used for maternal anesthesia during pregnancy. Sevoflurane exposure of rats at mid-gestation can cause abnormal development of the central nervous system in their offspring. Sevoflurane is known to increase the expression of cannabinoid...

Mechanistic insight into sevoflurane-associated developmental neurotoxicity.

by SmartTots | Feb 14, 2023 | Preclinical Articles, Research Articles

Abstract With the development of technology, more infants receive general anesthesia for surgery, other interventions, or clinical examination at an early stage after birth. However, whether general anesthetics can affect the function and structure of the developing...

Inhibition of ERK/CREB signaling contributes to postoperative learning and memory dysfunction in neonatal rats.

by SmartTots | Feb 14, 2023 | Preclinical Articles, Research Articles

Abstract Exposure to surgery with anesthesia early in life may lead to abnormal behavior, learning, and memory in humans. Pre-clinical studies have suggested a critical role of glial cell-derived neurotrophic factor (GDNF) in these effects. We hypothesize that the...

Tandem mass tag-based quantitative proteomic analysis of effects of multiple sevoflurane exposures on the cerebral cortex of neonatal and adult mice.

by SmartTots | Feb 14, 2023 | Preclinical Articles, Research Articles

Abstract Introduction: Sevoflurane is the most commonly used general anesthetic in pediatric surgery, but it has the potential to be neurotoxic. Previous research found that long-term or multiple sevoflurane exposures could cause cognitive deficits in newborn mice but...

Calpain-TRPC6 signaling pathway contributes to propofol-induced developmental neurotoxicity in rats.

by SmartTots | Feb 14, 2023 | Preclinical Articles, Research Articles

Abstract Growing animal studies suggest a risk of neuronal damage following early childhood exposure to anesthesia and sedation drugs including propofol. Inhibition of transient receptor potential canonical 6 (TRPC6) degradation has been shown to protect neurons from...
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Recent Posts

  • Z-DNA/RNA Binding Protein 1 Senses Mitochondrial DNA to Induce Receptor-Interacting Protein Kinase-3/Mixed Lineage Kinase Domain-Like-Driven Necroptosis in Developmental Sevoflurane Neurotoxicity.
  • Embryonic exposure to fentanyl induces behavioral changes and neurotoxicity in zebrafish larvae.
  • Sevoflurane induces neurotoxic effects on developing neurons through the WNK1/NKCC1/Ca2+ /Drp-1 signalling pathway.
  • Single-nucleus atlas of sevoflurane-induced hippocampal cell-type- and sex-specific effects during development in mice.
  • Ketamine impairs growth cone and synaptogenesis in human GABAergic projection neurons via GSK-3β and HDAC6 signaling.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

90 New Montgomery Street
Suite 412
San Francisco, CA 94105
Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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