by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Ketamine, a noncompetitive N-methyl D-aspartate (NMDA) receptor antagonist, is widely used in pediatric clinical practice. The neuroprotective and neurotoxic effects of ketamine on brain neurons during development remain controversial. The reason may be...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Aims: Mid-gestational sevoflurane exposure may induce notable long-term neurocognitive impairment in offspring. This study was designed to investigate the role and potential mechanism of ferroptosis in developmental neurotoxicity induced by sevoflurane in the...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract General anesthetics are potent neurotoxins when given during early development, causing apoptotic deletion of substantial number of neurons and persistent neurocognitive and behavioral deficits in animals and humans. The period of intense synaptogenesis...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract There is increasing concern about the potential effects of anesthesia exposure on the developing brain. The effects of relatively brief anesthesia exposures used repeatedly to acquire serial magnetic resonance imaging scans could be examined prospectively in...
by SmartTots | May 1, 2023 | Preclinical Articles, Research Articles
Abstract Background: Sevoflurane is an inhalational anesthetic for the induction and maintenance of general anesthesia in pediatric surgery. However, few studies have paid attention to the multiple organ toxicity and the mechanism behind it. Methods: Inhalation...
by SmartTots | May 1, 2023 | Preclinical Articles, Research Articles
Abstract An increasing number of studies reveal the deleterious effects of isoflurane (Iso) exposure during pregnancy on offspring cognition. However, no effective therapeutic strategy for Iso-induced deleterious effects has been well developed. Angelicin exerts an...
