by SmartTots | Jan 4, 2024 | Preclinical Articles, Research Articles
Abstract Sevoflurane (SEV) is a commonly used anesthetic in pediatric surgery. Recent studies reported that repeated use of SEV contributes to cognitive impairment. Engeletin has been discovered to exert anti-inflammatory effects in various diseases. However, the...
by SmartTots | Jan 4, 2024 | Preclinical Articles, Research Articles
Abstract Background: Sevoflurane is a widely used anesthetic in infants. However, long and repeated exposure to this drug can cause developmental neurotoxicity. This study aimed to investigate the role and mechanism of circular RNA DLGAP4 (circDLGAP4) in...
by SmartTots | Jan 4, 2024 | Preclinical Articles, Research Articles
Abstract Objective: To investigate whether propofol can cause injury to hippocampal mitochondria in neonatal rats and the regulation of excitatory amino acid receptor AMPA receptor. Methods: Forty-eight Sprague-Dawley (SD) rats aged 7 days were randomly divided into...
by SmartTots | Jan 4, 2024 | Preclinical Articles, Research Articles
Abstract Objective: To explore the molecular mechanism of propofol-induced apoptosis in oligodendrocytes. Methods: Fortyfive neonatal (7 days old) SD rats were randomized into 3 groups (n=15) for a single intraperitoneal injection of saline (control), long chain fat...
by SmartTots | Jan 4, 2024 | Preclinical Articles, Research Articles
Abstract Purpose: Repeated exposure of infant rhesus macaques to sevoflurane induces neurotoxicity and is associated with neurocognitive impairment in later life. We aimed to investigate the effect of repeated sevoflurane exposure on the expression of proteins in the...
by SmartTots | Jan 4, 2024 | Preclinical Articles, Research Articles
Abstract Background: Melatonin is known to have protective effects in aging, neurodegenerative disorders and mitochondria-related diseases, while there is a poor understanding of the effects of melatonin treatment on mitophagy in neonatal cognitive dysfunction after...
