by SmartTots | Apr 28, 2022 | Research Articles
Abstract Background Sevoflurane is a volatile anesthetic that is widely used in pediatric anesthesia due to its low toxicity. However, whether neonatal exposure to sevoflurane induces long-lasting cognitive impairment remains unclear. It has reported that neuronal...
by SmartTots | Apr 28, 2022 | Research Articles
Abstract General anesthetics are capable of inducing neuronal apoptosis during the rapid synaptogenesis of immature mammalian brains. In this vulnerable time window, physiological apoptosis also occurs to eliminate excess and inappropriately integrated neurons. We...
by SmartTots | Apr 28, 2022 | Research Articles
Abstract Sevoflurane (Sev) is a widely used inhalational anesthetic for general anesthesia in children. Previous studies have confirmed that multiple exposures to inhaled anesthetic can induce long-term neurotoxicity in newborn mice. However, the underlying mechanisms...
by SmartTots | Apr 28, 2022 | Research Articles
Abstract Background: Isoflurane can significantly induce inflammation in children without surgical stress. The toll-like receptor 4 (TLR4) is closely related to noninfectious inflammation in the brain. Objectives: To investigate the role of TLR4-small interfering RNA...
by SmartTots | Apr 28, 2022 | Research Articles
Abstract The current study aimed to examine the effects of echinacoside on cognitive impairment in mice after exposure to sevoflurane. To examine the role of FOXO1, si-FOXO1 and si-con were injected into the hippocampus through the left lateral cerebral ventricles....
by SmartTots | Apr 28, 2022 | Research Articles
Abstract Inhalation anesthetics have been shown to cause neurodevelopmental disorders and neurotoxic effects. In this study, we aimed to investigate the effect of resveratrol on the possible neurotoxic effect of sevoflurane and the brain-derived neurotrophic factor...
