by SmartTots | Jan 18, 2022 | Research Articles
Abstract Patients who have surgery during the first few years of their lives may have an increased risk of behavioral abnormality. Our previous study has shown a role of glial cell-derived neurotrophic factor (GDNF) in neonatal surgery-induced learning and memory...
by SmartTots | Jan 18, 2022 | Research Articles
Abstract Human and animal studies have elucidated the apparent neurodevelopmental effects resulting from neonatal anesthesia. Observations of learning and behavioral deficits in children, who were exposed to anesthesia early in development, have instigated a flurry of...
by SmartTots | Jan 18, 2022 | Research Articles
Abstract Purpose: Our study introduces a novel anesthetic protocol for neonates without using volatile agents with the goal to minimize potentially neurotoxic and pro-apoptotic agents. The authors evaluated the short-term safety and efficacy of our anesthetic protocol...
by SmartTots | Jan 18, 2022 | Research Articles
Abstract Anesthetic agents disrupt neurodevelopment in animal models, but evidence in humans is mixed. The morphologic and behavioral changes observed across many species predicted that deficits should be seen in humans, but identifying a phenotype of injury in...
by SmartTots | Nov 18, 2021 | Research Articles
This book chapter, including a section on the pediatric population, explores the issues of concern and clinical significance of the neurotoxic side effects of general anesthesia. The authors 1) summarize research findings in young animals that demonstrate...
by SmartTots | Nov 18, 2021 | Research Articles
Recent studies by Ing and colleagues (Ing) address the association between surgery, general anesthesia, ADHD (attention deficit hyperactivity disorder), and other mental illnesses in young children. Frisch and colleagues (Frisch) raise a methodological issue and call...
