by SmartTots | Jan 4, 2024 | Clinical Articles, Research Articles
Abstract Anesthesia-induced neurotoxicity is a major concern for anesthetists for more than 20 years. Many experimental and clinical studies have been conducted on this topic since late 1990s. However, bibliometric analysis of these papers has not been reported. In...
by SmartTots | Jan 4, 2024 | Clinical Articles, Research Articles
Abstract Background and objectives: Early exposure to analgesics and sedatives is a key concern for later learning disorders in children. The hippocampus, a key region for learning and memory, may be selectively affected by exposure to benzodiazepines that are...
by SmartTots | Nov 3, 2023 | Preclinical Articles, Research Articles
Abstract Prenatal exposure to anesthetics has raised increasing attention about the neuronal development in offspring. Animal models are usually used for investigation. As a new drug, esketamine is the s-isoform of ketamine and is twice as potent as the racemic...
by SmartTots | Nov 3, 2023 | Preclinical Articles, Research Articles
Abstract Narrowing down the histopathological changes in the brain after early-life exposure to general anaesthesia has presented a consistent challenge for preclinical models of anaesthetic neurotoxicity. Using resting-state functional magnetic resonance imaging, in...
by SmartTots | Nov 3, 2023 | Preclinical Articles, Research Articles
Abstract Propofol is one of the most used intravenous anesthetic agents, which is widely used in clinical anesthesia induction and maintenance of pediatric patients. Exposure of the developing brain to propofol has been reported to lead to adverse brain changes, which...
by SmartTots | Nov 3, 2023 | Preclinical Articles, Research Articles
Abstract In the last two decades, safety concerns about general anesthesia (GA) arose from studies documenting brain cell death in various pharmacological conditions and animal models. Nowadays, a thorough characterization of sevoflurane-induced apoptosis in the...
