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Apamin, an SK2 Inhibitor, Attenuated Neonatal Sevoflurane Exposures Caused Cognitive Deficits in Mice through the Regulation of Hippocampal Neuroinflammation.

by SmartTots | Nov 3, 2023 | Preclinical Articles, Research Articles

Abstract Cognitive dysfunction induced by anesthesia in the infant is a crucial clinical issue that is still being debated and the focus of concern for the parents. However, the mechanism of cognitive decline caused by anesthesia and the corresponding treatment...

Neuron-Derived Exosomes Mediate Sevoflurane-Induced Neurotoxicity in Neonatal Mice Via Transferring lncRNA Gas5 and Promoting M1 Polarization of Microglia.

by SmartTots | Nov 3, 2023 | Preclinical Articles, Research Articles

Abstract Sevoflurane exposure during rapid brain development induces neuronal apoptosis and causes memory and cognitive deficits in neonatal mice. Exosomes that transfer genetic materials including long non-coding RNAs (lncRNAs) between cells play a critical role in...

Early-in-Life Isoflurane Exposure Alters Resting-State Functional Connectivity in Juvenile Non-human Primates.

by SmartTots | Nov 3, 2023 | Preclinical Articles, Research Articles

Abstract Background Clinical studies suggest that anaesthesia exposure early in life affects neurobehavioural development. We designed a non-human primate (NHP) study to evaluate cognitive, behavioural, and brain functional and structural alterations after isoflurane...

Innovations in Diagnostic and Treatment Options for Pediatric Epilepsy and their Anesthetic Implications.

by SmartTots | Nov 3, 2023 | Clinical Articles, Research Articles

Abstract Purpose of review: To provide an overview of anesthetic techniques for innovative diagnostic and therapeutic epilepsy procedures performed on pediatric patients. Recent findings: Recent studies have been published on the anesthetic consideration for...

Perioperative Management of Infant Inguinal Hernia Surgery; a Review of the Recent Literature.

by SmartTots | Nov 3, 2023 | Clinical Articles, Research Articles

Abstract Inguinal hernia surgery is one of the most common electively performed surgeries in infants. The common nature of inguinal hernia combined with the high-risk population involving a predominance of preterm infants makes this a particular area of interest for...

Neurobehavioral Effects of General Anesthesia and Cochlear Implantation on Hearing-Impaired Infants: a Prospective Observational Cohort Study.

by SmartTots | Nov 3, 2023 | Clinical Articles, Research Articles

Abstract Introduction: The potential adverse effects of prolonged exposure to anesthetics in pediatric patients with severe-to-profound sensorineural hearing loss remain unclear. This study aimed to examine whether early bilateral cochlear implantation involving...
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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