by SmartTots | Jan 4, 2024 | Preclinical Articles, Research Articles
Abstract Objective: To investigate whether propofol can cause injury to hippocampal mitochondria in neonatal rats and the regulation of excitatory amino acid receptor AMPA receptor. Methods: Forty-eight Sprague-Dawley (SD) rats aged 7 days were randomly divided into...
by SmartTots | Jan 4, 2024 | Preclinical Articles, Research Articles
Abstract Objective: To explore the molecular mechanism of propofol-induced apoptosis in oligodendrocytes. Methods: Fortyfive neonatal (7 days old) SD rats were randomized into 3 groups (n=15) for a single intraperitoneal injection of saline (control), long chain fat...
by SmartTots | Jan 4, 2024 | Preclinical Articles, Research Articles
Abstract Purpose: Repeated exposure of infant rhesus macaques to sevoflurane induces neurotoxicity and is associated with neurocognitive impairment in later life. We aimed to investigate the effect of repeated sevoflurane exposure on the expression of proteins in the...
by SmartTots | Jan 4, 2024 | Preclinical Articles, Research Articles
Abstract Background: Melatonin is known to have protective effects in aging, neurodegenerative disorders and mitochondria-related diseases, while there is a poor understanding of the effects of melatonin treatment on mitophagy in neonatal cognitive dysfunction after...
by SmartTots | Jan 4, 2024 | Preclinical Articles, Research Articles
Abstract Aims: Sevoflurane is widely used for general anesthesia in children. Previous studies reported that multiple neonatal exposures to sevoflurane can induce long-term cognitive impairment in adolescent rats, but the underlying mechanisms were not defined....
by SmartTots | Jan 4, 2024 | Preclinical Articles, Research Articles
Abstract Esketamine, a widely used intravenous general anesthetic, is also employed for obstetric and pediatric anesthesia, and depression treatment. However, concerns regarding esketamine abuse have emerged. Moreover, the potential in vivo toxicity of esketamine on...
