by SmartTots | Jan 4, 2024 | Preclinical Articles, Research Articles
Abstract Background: Sevoflurane, one of the most commonly used general anesthetics for pediatric anesthesia, has recently gained significant attention in both preclinical and clinical settings due to its potential neurotoxicity in the developing brain. Tau...
by SmartTots | Nov 3, 2023 | Preclinical Articles, Research Articles
Abstract Prenatal exposure to anesthetics has raised increasing attention about the neuronal development in offspring. Animal models are usually used for investigation. As a new drug, esketamine is the s-isoform of ketamine and is twice as potent as the racemic...
by SmartTots | Nov 3, 2023 | Preclinical Articles, Research Articles
Abstract Narrowing down the histopathological changes in the brain after early-life exposure to general anaesthesia has presented a consistent challenge for preclinical models of anaesthetic neurotoxicity. Using resting-state functional magnetic resonance imaging, in...
by SmartTots | Nov 3, 2023 | Preclinical Articles, Research Articles
Abstract Propofol is one of the most used intravenous anesthetic agents, which is widely used in clinical anesthesia induction and maintenance of pediatric patients. Exposure of the developing brain to propofol has been reported to lead to adverse brain changes, which...
by SmartTots | Nov 3, 2023 | Preclinical Articles, Research Articles
Abstract In the last two decades, safety concerns about general anesthesia (GA) arose from studies documenting brain cell death in various pharmacological conditions and animal models. Nowadays, a thorough characterization of sevoflurane-induced apoptosis in the...
by SmartTots | Nov 3, 2023 | Preclinical Articles, Research Articles
Abstract Cognitive dysfunction induced by anesthesia in the infant is a crucial clinical issue that is still being debated and the focus of concern for the parents. However, the mechanism of cognitive decline caused by anesthesia and the corresponding treatment...
