by SmartTots | Mar 2, 2022 | Research Articles
Abstract Background: Exposure to general anaesthesia in children may be related to deficits in certain areas of cognition. It is unclear if these deficits could be measured in the immediate postoperative period in young children. The goal of the current study was to...
by SmartTots | Feb 1, 2022 | Research Articles
The Pediatric Anesthesia & Neurodevelopment Assessment (PANDA) project is a large, multi-center study based at the Morgan Stanley Children’s Hospital of New York (Columbia University). The project aims to examine two groups of children – those who have been...
by SmartTots | Jan 18, 2022 | Research Articles
Abstract Long-lasting cognitive impairment in juveniles undergoing repeated general anesthesia has been observed in numerous preclinical and clinical studies, yet, the underlying mechanisms remain unknown and no preventive treatment is available. We found that daily...
by SmartTots | Jan 18, 2022 | Research Articles
Abstract Volatile anesthetics (VAs) are widely used in medicine, but the mechanisms underlying their effects remain ill-defined. Though routine anesthesia is safe in healthy individuals, instances of sensitivity are well documented, and there has been significant...
by SmartTots | Jan 18, 2022 | Research Articles
Abstract Background: Fetal surgery is part of modern fetal medicine, and some procedures, such as fetal spina bifida repair, are performed under general anesthesia. Fetuses are operated on in a time window when the developing brain is extremely vulnerable to external,...
by SmartTots | Jan 18, 2022 | Research Articles
Abstract General anesthetics are neurotoxic to the developing rodent and primate brains leading to neurocognitive and socio-affective impairment later in life. In addition, sleep patterns are important predictors of cognitive outcomes. Yet, little is known about how...
