by SmartTots | Jun 2, 2017 | News
The European anesthesiology societies have developed and published a consensus statement in response to the December FDA warning. Copies of the statement and related European Journal of Anesthesiology editorial are attached for your information. Use of anaesthetics...
by SmartTots | May 16, 2017 | Research Articles
Abstract The year 2016 marked the 15th anniversary since anesthesia-induced developmental neurotoxicity and its resulting cognitive dysfunction were first described. Since that time, multiple scientific studies have supported these original findings and investigated...
by SmartTots | May 16, 2017 | Research Articles
Abstract Increasing studies have demonstrated that sevoflurane can induce neurotoxicity in the developing brains. JNK normally promotes apoptosis. It was hypothesized that sevoflurane affected the proliferation and differentiation of FNSCs and induced cell apoptosis,...
by SmartTots | May 16, 2017 | Research Articles
Abstract The association of general anesthesia with developmental neurotoxicity, while nearly impossible to study in pediatric populations, is clearly demonstrable in a variety of animal models from rodents to nonhuman primates. Nearly all general anesthetics tested...
by SmartTots | May 16, 2017 | Research Articles
Abstract Prolonged ketamine exposure in neonates at anesthetic doses is known to cause long-term impairments of learning and memory. A current theoretical mechanism explains this phenomenon as being neuro-excitotoxicity mediated by compensatory upregulation of...
