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National Center for Toxicological Research (NCTR)

by SmartTots | Jun 1, 2022 | Research Articles

FDA’s National Center for Toxicological Research (NCTR) is conducting non-clinical studies in both rodents and nonhuman primates to assess: 1) the mechanisms underlying the neurotoxicity associated with clinically-relevant general anesthetics such as ketamine,...

Pediatric Anesthesia NeuroDevelopment Assessment (PANDA Study)

by SmartTots | Feb 1, 2022 | Research Articles

The Pediatric Anesthesia & Neurodevelopment Assessment (PANDA) project is a large, multi-center study based at the Morgan Stanley Children’s Hospital of New York (Columbia University). The project aims to examine two groups of children – those who have been...

Mayo Clinic Research: MASK (Mayo Safety in Kids) Study

by SmartTots | Jul 1, 2021 | Research Articles

Researchers at the Mayo Clinic in collaboration with the National Center for Toxicological Research (NCTR) are conducting a population-based study of long-term cognitive development in a large cohort of Rochester, MN children. The study compares performance of...

SmartTots Panel on Pediatric Anesthesia Neurotoxicity Research

by SmartTots | May 23, 2021 | Research Articles

Moderated by SmartTots Medical Officer, Dean Andropoulos, MD Pre-Clinical Research: What are the priorities? Laszlo Vutskits, MD, PhD Challenges with Clinical Studies and Update on the T-REX Trial -Andrew Davidson, MBBS, MD, FANZCA Clinical Anesthetic Neurotoxicity:...

Anesthesia and Neurotoxicity Study Design, Execution, and Reporting in the Non-Human Primate: A Deep Dive

by SmartTots | May 23, 2021 | Research Articles

Feng Gao, MD, Investigator Baylor College of Medicine What is the quality of non-human primate (NHP) studies used to support the concern for anesthesia-related neurodevelopmental delays in children? This poster session describes a systematic review of 18 manuscripts...
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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