by SmartTots | Jul 7, 2022 | Research Articles
“A substitute shines brightly as a king until a king be by” Portia, Act 5, Scene 1, The Merchant of Venice, William Shakespeare. Nonhuman primates (NHPs) have been important surrogates for modeling human diseases. In the field of perioperative medicine, preclinical...
by SmartTots | Jul 7, 2022 | Research Articles
Abstract Importance Clinical studies of neurodevelopmental outcomes after anesthetic exposure have evaluated a range of outcomes with mixed results. Objective To examine via meta-analyses the associations between exposure to general anesthesia and domain-specific...
by SmartTots | Jul 7, 2022 | Research Articles
Abstract Objective: To evaluate possible negative long-term effects of neonatal exposure to pain, opioids and anesthetics in children and adolescents. Study design: We studied five unique groups of children recruited from well-documented neonatal cohorts with a...
by SmartTots | Jul 7, 2022 | Research Articles
Abstract Nitrous oxide is one of the most commonly used inhalational anesthetic agents used in practice. It is a cost-effective, pleasant, safe, and versatile anesthetic agent with many desirable properties like good quality analgesia, decreased awareness, accelerated...
by SmartTots | Jul 7, 2022 | Research Articles
Abstract Background: General anesthesia (GA) is known to worsen neural outcomes in animals, but human research assessing early-life GA exposure and neurodevelopment show inconsistent findings. We investigated the effects of a single GA exposure for minor surgery on...
by SmartTots | Jun 1, 2022 | Research Articles
FDA’s National Center for Toxicological Research (NCTR) is conducting non-clinical studies in both rodents and nonhuman primates to assess: 1) the mechanisms underlying the neurotoxicity associated with clinically-relevant general anesthetics such as ketamine,...
